Chemotherapy was potentiated by E7449 and single agent had substantial antitumor activity in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon most cancers cell lines, probably by TNKS inhibition. In line with this chance, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and considerably altered expression of Wnt https://mylesxdhln.dm-blog.com/29460786/the-2-minute-rule-for-apigenin