Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators within the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have discovered recurrent mutations in genes regulating tumor cell-microenvironment interactions,... https://thomasu641lsb8.bloggazzo.com/profile