Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals within the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have determined recurrent mutations in genes regulating tumor mobile-microenvironment interact... https://alicew097jzn5.ageeksblog.com/profile