Here, we clearly show that conolidine, a all-natural analgesic alkaloid Employed in regular Chinese medication, targets ACKR3, thereby supplying more evidence of the correlation involving ACKR3 and ache modulation and opening alternative therapeutic avenues with the remedy of Persistent soreness. All emblems, registered logos and service-marks pointed out on https://charlesc925iey3.wikijournalist.com/user