And finally, clonidine boosts neuraxial opioids and, in combination with fentanyl, interacts in an additive manner, which may lessen the dose of every component by 60% for postoperative analgesia. Clonidine treats high blood pressure level by stimulating α2 receptors within the brainstem, which decreases peripheral vascular resistance, lowering hypertension. https://bookmarkyourpage.com/story5201907/onolidine-an-overview