Pentobarbital will decrease the level or effect of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of buspirone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. When barbiturates like Nembutal are abused, they are not usually the primary drug of abuse. Like https://thebookmarkfree.com/story20419626/esamina-la-relazione-sulla-pentobarbital-vs-phenobarbital